Organophosphorus insecticide dichlorvos inhibits fatty acid amide hydrolase in the male reproductive organs of rats
نویسندگان
چکیده
منابع مشابه
Fatty acid amide hydrolase substrate specificity.
Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnat...
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چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولFundamental Toxicological Sciences
Organophosphorus (OP) insecticides are used worldwide to protect agricultural crops and dwellings. These chemicals phosphorylate diverse serine hydrolases, including acetylcholinesterase. Among them, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), components of the endocannabinoid signaling system (ECS) in male reproductive organs, are candidate targets of OP insecticide-i...
متن کاملEpigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
OBJECTIVE Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. METHODS We have studied the gene expression status and the epigenetic regulation of ECS components in ...
متن کاملDefects in fatty acid amide hydrolase 2 in a male with neurologic and psychiatric symptoms
BACKGROUND Fatty acid amide hydrolase 2 (FAAH2) is a hydrolase that mediates the degradation of endocannabinoids in man. Alterations in the endocannabinoid system are associated with a wide variety of neurologic and psychiatric conditions, but the phenotype and biochemical characterization of patients with genetic defects of FAAH2 activity have not previously been described. We report a male wi...
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ژورنال
عنوان ژورنال: Fundamental Toxicological Sciences
سال: 2017
ISSN: 2189-115X
DOI: 10.2131/fts.4.201